human coronavirus oc 43 hcov oc43  (ATCC)

Journal: Cell Reports Medicine

Article Title: Systemic and mucosal immune signatures of protection against SARS-CoV-2 transmission in humans

doi: 10.1016/j.xcrm.2025.102505

Figure Lengend Snippet: Longitudinal antibody response to SARS-CoV-2, HCoV-OC43, and HCoV-229E proteins in the systemic compartment Serum from participants was analyzed at baseline and at days 3, 7, and 28 post-enrollment. (A) IgG, IgM, and IgA response for SARS-CoV-2 full-length protein and S1, S2, and RBD domains according to groups (index, positive cases, negative cases). Dots represent the GMT, and bars indicate 95% CI. (B) IgG, IgM, and IgA response for HCoV-OC43 full-length protein and S1 and S2 domains according to groups (index, positive cases, negative cases). Dots represent the GMT, and bars indicate 95% CI. (C) IgG, IgM, and IgA response for HCoV-229E full-length protein according to groups (index, positive cases, negative cases). Dots represent the GMT, and bars indicate 95% CI. ∗ p ≤ 0.05. Data on antibody were compared by multiple comparison analysis (Kruskal-Wallis test); if multiple comparison was statistically significant (∗ p ≤ 0.05), a pairwise comparison was performed and the Bonferroni correction for multiple tests was applied. Data on two-by-two comparison are shown in .

Article Snippet: OC43 full-length spike protein , Sino Biological , Cat#40607-V08B.

Techniques: Comparison

Journal: Cell Reports Medicine

Article Title: Systemic and mucosal immune signatures of protection against SARS-CoV-2 transmission in humans

doi: 10.1016/j.xcrm.2025.102505

Figure Lengend Snippet: Fold induction of SARS-CoV-2 and HCoV-OC43 S1 and S2 domains Boxplot diagrams of geometric mean fold rise antibody titers against SARS-CoV-2 and HCoV-OC43 S1 and S2 domains at different time points (days 3, 7, and 28 post-enrollment) according to groups (index, positive cases, negative cases). (A) Box-and-whisker diagrams of fold induction IgG, IgM, and IgA titers against SARS-CoV-2 S1 and S2 domains at different time points according to groups (index, positive cases, negative cases). Box indicates IQR (Q1–Q3) with line indicating median and error bars indicating minimum and maximum. (B) Box-and-whisker diagrams of fold induction IgG, IgM, and IgA titers against HCoV-OC43 S1 and S2 domains at different time points according to groups (index, positive cases, negative cases). Box indicates IQR (Q1–Q3) with line indicating median and error bars indicating minimum and maximum. Kruskal-Wallis test was performed to compare differences at each time point between the subdomains. Statistical significance was considered when p < 0.05 (∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001).

Article Snippet: OC43 full-length spike protein , Sino Biological , Cat#40607-V08B.

Techniques: Whisker Assay

Journal: Cell Reports Medicine

Article Title: Systemic and mucosal immune signatures of protection against SARS-CoV-2 transmission in humans

doi: 10.1016/j.xcrm.2025.102505

Figure Lengend Snippet: Binomial logistic regression of preexisting SARS-CoV-2, HCoV-OC43, and HCoV-229E antibody levels and the probability of infection upon SARS-CoV-2 exposure in the CIDS cohort (A) Violin plot of IgG, IgM, and IgA baseline antibody titers (log10 AUC) for SARS-CoV-2-S, HCoV-OC43-S, and HCoV-229e-S full-length proteins in index, positive cases, and negative cases groups. Median (continuous black line), and IQR (Q1–Q3) values (discontinued lines) are represented. Pairwise comparisons adjusted by the Bonferroni correction for multiple test has been performed, and significance of ∗ p < 0.05 is shown. (B–D) Scatterplot diagrams showing the inverse relationship between the predicted probability of infection (PP infection, %) and immunoglobulin levels for the indicated SARS-CoV-2 antigens: S (full-length), S1, RBD, and S2; (C) HCoV-OC43: S (full-length), S1, and S2; and (D) HCoV-22E S (full-length). Logistic regression analysis has been performed for each variable individually, and significance of ∗ p < 0.05 is shown.

Article Snippet: OC43 full-length spike protein , Sino Biological , Cat#40607-V08B.

Techniques: Infection

Journal: Cell Reports Medicine

Article Title: Systemic and mucosal immune signatures of protection against SARS-CoV-2 transmission in humans

doi: 10.1016/j.xcrm.2025.102505

Figure Lengend Snippet: Multi-assay modeling of systemic signatures of protection against SARS-CoV-2 infection (A) Multivariate logistic regression model analyzing the potential protection of baseline antibodies against S1 versus S2 domains of SARS-CoV-2 virus for IgG, IgM, and IgA isotypes. (B) Multivariate logistic regression model analyzing the potential protection of baseline antibodies against S1 versus RBD domains of SARS-CoV-2 virus for IgG, IgM, and IgA isotypes. (C) Multivariate logistic regression model analyzing the potential protection of baseline antibodies against S1 versus S2 domains of HCoV-OC43 virus for IgG, IgM, and IgA isotypes. (D) Multivariate logistic regression model analyzing the potential protection of baseline antibodies against the S2 domain of HCoV-OC43 virus for IgG, IgM, and IgA isotypes. (E) Multivariate logistic regression model analyzing the potential protection of anti-S1 IgG SARS-CoV-2 and anti-S2 IgM HCoV-OC43 from SARS-CoV-2 infection. OR and 95% CIs are shown for all the variables. p values for the significant variables are shown. All the models are adjusted by potential confounding factors (age and sex).

Article Snippet: OC43 full-length spike protein , Sino Biological , Cat#40607-V08B.

Techniques: Infection, Virus

Journal: Cell Reports Medicine

Article Title: Systemic and mucosal immune signatures of protection against SARS-CoV-2 transmission in humans

doi: 10.1016/j.xcrm.2025.102505

Figure Lengend Snippet: Multi-assay modeling of mucosal signatures of protection against SARS-CoV-2 infection Nasopharyngeal swab samples from participants were analyzed at baseline and at days 3, 7, and 28 post-enrollment. (A–H) IgG, IgM, IgA, and secretory IgA (sIgA) response for (A) SARS-CoV-2 S and (B) HCoV-OC43 S proteins according to groups (index, positive cases, and negative cases) on the upper respiratory tract. Dots represent the GMT, and bars indicate 95% CI. Fold change antibody titers against (C) SARS-CoV-2 and (D) HCoV-OC43 S protein represented as boxplot. Box indicates IQR (Q1–Q3), with horizontal line at median and whiskers representing minimum and maximum. Binomial logistic regression of pre-existing (E) SARS-CoV-2 and (F) HCoV-OC43 antibody levels and the probability of SARS-CoV-2 infection. Scatterplot diagrams show the inverse relationship between the PP infection % and anti-SARS-CoV-2 S IgG, IgM, IgA, and sIgA mucosal levels. Multivariate logistic regression model analyzing the potential protection of (G) anti-SARS-CoV-2 S and (H) anti-HCoV-OC43 S IgG, IgM, IgA, and sIgA mucosal antibody levels at enrollment. (I) Multivariate logistic regression model analyzing the potential protection of mucosal anti-S IgG SARS-CoV-2 and anti-S IgA HCoV-OC43 antibody levels at enrollment from SARS-CoV-2 infection. (J) Mixed multivariate logistic regression analysis of the potential protection of systemic (SARS-CoV-2 S1 IgG and HCoV-OC43 S2 IgM) and mucosal (SARS-CoV-2 S IgG and HCoV-OC43 S IgA) antibody levels at enrollment for SARS-CoV-2 infection. Data on antibody were compared by multiple comparison analysis (Kruskal-Wallis test); if multiple comparison was statistically significant (∗ p ≤ 0.05), a pairwise comparison was performed and the Bonferroni correction for multiple tests was applied. Data on two-by-two comparison are shown in and .

Article Snippet: OC43 full-length spike protein , Sino Biological , Cat#40607-V08B.

Techniques: Infection, Comparison